Mitochondrial fission inhibitor Mdivi-1 alleviates lipopolysaccharide-induced parvalbumin interneurons dysregulation and cognitive impairments in a mouse model of sepsis-associated encephalopathy

Mitochondrial fission inhibitor Mdivi-1 alleviates lipopolysaccharide-induced parvalbumin interneurons dysregulation and cognitive impairments in a mouse model of sepsis-associated encephalopathy

Introduction:Dysregulation of parvalbumin (PV) interneurons has been implicated in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain poorly understood, and effective treatments are lacking. Given the high energy demands of PV interneurons and the emerging role of mitochond...

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Main Authors: Lei Dai, Shuxin Gu, Yibao Zhang, Siqi Ma, Peishan Wang, Jingyun Zhang, Cai Wang, Gaowei Su, Qun Fu, Wei Zhou, Yunxia Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
sepsis-associated encephalopathy
Mdivi-1
parvalbumin interneurons
neuroinflammation
cognitive impairment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1525028/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1525028/full

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