Identification of <i>Streptococcus pneumoniae</i> Sortase A Inhibitors and the Interactive Mechanism

Identification of <i>Streptococcus pneumoniae</i> Sortase A Inhibitors and the Interactive Mechanism

<i>Streptococcus pneumoniae</i> (<i>S. pneumoniae</i>) Sortase A (SrtA) anchors virulence proteins to the surface of the cell wall by recognizing and cleaving the LPXTG motif. These toxins help bacteria adhere to and colonize host cells, promote biofilm formation, and trigger...

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Bibliographic Details
Main Authors: Guizhen Wang, Jiahui Lu, Jingyao Wen, Yifan Duan, Hanbing Zhou, Xinli Peng, Zhandong Li
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Crystals
Subjects:
Sortase A
lead materials
<i>S. pneumoniae</i>
molecular simulation
anti-infection
Online Access:https://www.mdpi.com/2073-4352/15/7/594
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