TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages.

TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages.

Since most genetically modified mice are C57BL/6 background, a mouse-adapted SARS-CoV-2 that causes lethal infection in young C57BL/6 mice is useful for studying innate immune protection against SARS-CoV-2 infection. Here, we established two mouse-adapted SARS-CoV-2, ancestral and Delta variants, by...

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Main Authors: Moe Kobayashi, Nene Kobayashi, Kyoka Deguchi, Seira Omori, Minami Nagai, Ryutaro Fukui, Isaiah Song, Shinji Fukuda, Kensuke Miyake, Takeshi Ichinohe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012776
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https://doi.org/10.1371/journal.ppat.1012776

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