Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity

Abstract Klotho, a well-known aging suppressor protein, has been implicated in neuroprotection and the regulation of neuronal senescence. While previous studies have demonstrated its anti-aging properties in human brain organoids, its potential to mitigate neurodegenerative processes triggered by β-...

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Bibliographic Details
Main Authors: Mohammed R. Shaker, Salam Salloum-Asfar, Rowaida Z. Taha, Ibrahim Javed, Ernst J. Wolvetang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Brain
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Online Access:https://doi.org/10.1186/s13041-025-01199-6
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