Serum Reactivity Against Bacterial Pyruvate Dehydrogenase: Increasing the Specificity of Anti-Mitochondrial Antibodies for the Diagnosis of Primary Biliary Cirrhosis

Serum Reactivity Against Bacterial Pyruvate Dehydrogenase: Increasing the Specificity of Anti-Mitochondrial Antibodies for the Diagnosis of Primary Biliary Cirrhosis

Antimitochondrial antibodies (AMA) are the serum hallmark of primary biliary cirrhosis (PBC). However, AMA-positivity can be found in non-PBC sera when lower dilutions are used, thus raising issues about the specificity and sensitivity of the test. AMA reacts primarily with the lipoylated domains of...

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Main Authors: Hiroshi Miyakawa, Atsushi Tanaka, Carlo Selmi, Naomi Hosoya, Norikazu Mataki, Kentaro Kikuchi, Takashi Kato, Junya Arai, Toshihiro Goto, M. Eric Gershwin
Format: Article
Language:English
Published: Wiley 2006-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1080/17402520600668706
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http://dx.doi.org/10.1080/17402520600668706

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