Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase

The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for their role in cancer and inherited metabolic...

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Bibliographic Details
Main Authors: Kaylen R. Meeks, Alexandra N. Bogner, Jay C. Nix, John J. Tanner
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
X-ray crystallography
fragment-based lead discovery
enzyme inhibition
flavoenzyme
aldehyde dehydrogenase
proline catabolism
Online Access:https://www.mdpi.com/1420-3049/29/22/5408
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