A functional unbalance of TRPM8 and Kv1 channels underlies orofacial cold allodynia induced by peripheral nerve damage

A functional unbalance of TRPM8 and Kv1 channels underlies orofacial cold allodynia induced by peripheral nerve damage

Cold allodynia is a debilitating symptom of orofacial neuropathic pain resulting from trigeminal nerve damage. The molecular and neural bases of this sensory alteration are still poorly understood. Here, using chronic constriction injury (CCI) of the infraorbital nerve (IoN) (IoN-CCI) in mice, combi...

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Bibliographic Details
Main Authors: Ricardo Piña, Gonzalo Ugarte, Camilo Guevara, Richard Pino, Katherine Valdebenito, Sofía Romero, Ana Gómez del Campo, Víctor Hugo Cornejo, María Pertusa, Rodolfo Madrid
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
primary sensory neurons
thermotransduction
infraorbital nerve
IKD
AAV vectors
4-AP
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1484387/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1484387/full

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