Translesion synthesis of apurinic/apyrimidic site<?A3B2 ACK?>analogues by Y-family DNA polymerase Dbh from<?A3B2 ACK?>Sulfolobus acidocaldarius

Translesion synthesis of apurinic/apyrimidic site<?A3B2 ACK?>analogues by Y-family DNA polymerase Dbh from<?A3B2 ACK?>Sulfolobus acidocaldarius

Apurinic/apyrimidic (AP) sites are severe DNA damages and strongly block DNA extension by major DNA polymerases. Y-family DNA polymerases possess a strong ability to bypass AP sites and continue the DNA synthesis reaction, which is called translesion synthesis (TLS) activity. To investigate the effe...

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Bibliographic Details
Main Authors: Wang Weiwei, Zhou Huan, Peng Li, Yu Feng, Xu Qin, Wang Qisheng, He Jianhua, Liu Xipeng
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
translesion synthesis
<italic>Sulfolobus acidocaldariu</italic>s
Y-family DNA polymerase
Dbh
AP site analogues
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022045
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https://www.sciengine.com/doi/10.3724/abbs.2022045

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