Druggable proteins of Alistipes reveal promising antimicrobial targets against chronic intestinal inflammation

Druggable proteins of Alistipes reveal promising antimicrobial targets against chronic intestinal inflammation

IntroductionThe genus Alistipes consists of anaerobic, Gram-negative bacteria with 13 species that colonize the entire gastrointestinal tract and are a serious health concern. They contribute to gut dysbiosis, intestinal inflammation, colorectal cancer, and depression.MethodsTo explore potential the...

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Main Authors: Saman Sohail, Ayesha Wisal, Sobia Rana, Rao Muhammad Abid Khan, Asad Ullah, Farooq-Ahmad Khan, Muhammad Irfan, Muhammad Imran, Paulo V. S. D. Carvalho, Renato Rozental, Farzana Shaheen, Syed Shah Hassan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
Alistipes genera
subtractive genomics
druggable targets
TCM/ZINC inhibitors
pharmacokinetics
thermodynamics evaluation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555062/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1555062/full

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