Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors

Abstract Objective To investigate the metabolic remodeling and functional specialization of immune cells within the tumor microenvironment (TME) of bone tumors, including Ewing’s sarcoma, osteosarcoma, and giant cell tumor of bone, through high-resolution single-cell RNA sequencing (scRNA-seq) analy...

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Bibliographic Details
Main Authors: Jun Chen, Na Cui, Shao-Hui He, Chun-Yan Xia, Wei-Qing Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12967-025-06346-0
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