CAR-NK cells with dual targeting of PD-L1 and MICA/B in lung cancer tumor models

CAR-NK cells with dual targeting of PD-L1 and MICA/B in lung cancer tumor models

Abstract Background Chimeric antigen receptor (CAR) engineered natural killer (NK) cells have shown their efficacy and superiority against cancer and possess the potential to become off-the-shelf immunotherapy products. Nonetheless, some challenges associated with CAR-NK cells still exist including...

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Bibliographic Details
Main Authors: Lingtong Zhi, Zikang Zhang, Qing Gao, Chongye Shang, Wenhui He, Yuqing Wang, Changjiang Guo, Zhiyuan Niu, Wuling Zhu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
NK cells
PD-L1 nanoantibody
NKG2D
Pyroptosis
NK-tailored CAR
Human lung cancer
Online Access:https://doi.org/10.1186/s12885-025-13780-2
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https://doi.org/10.1186/s12885-025-13780-2

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