Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion

Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion

<b>Background/Objectives</b>: The increased use of antibiotics is raising concerns about environmental contamination and antibiotic resistance, exemplified by the case of cotrimoxazole, a widely prescribed combination of sulfamethoxazole and trimethoprim. After oral administration and ab...

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Bibliographic Details
Main Authors: Marieke A. J. Hof, Hessel de Haan, Stepan Stepanovic, Stephan J. L. Bakker, Eelko Hak, Gérard Hopfgartner, Frank Klont, TransplantLines Investigators
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Metabolites
Subjects:
humans
metabolomics
pharmacometabolomics
mass spectrometry
cohort studies
xenobiotics
Online Access:https://www.mdpi.com/2218-1989/15/7/473
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