Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Abstract Pancreatic cancer remains one of the most lethal malignancies in the digestive system, with limited available drugs and a need for improved efficacy. This unmet clinical need highlights the urgency to discover novel, highly efficient small‐molecule compounds. Herein, a novel cyano‐containin...

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Bibliographic Details
Main Authors: Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
anti‐pancreatic cancer
ferroptosis
novel artemisinin derivatives
PARP1 inhibitor
Online Access:https://doi.org/10.1002/advs.202501935
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https://doi.org/10.1002/advs.202501935

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