Pathogenesis of Hepatic Encephalopathy
Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuro...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/642108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559327245762560 |
|---|---|
| author | Irena Ciećko-Michalska Małgorzata Szczepanek Agnieszka Słowik Tomasz Mach |
| author_facet | Irena Ciećko-Michalska Małgorzata Szczepanek Agnieszka Słowik Tomasz Mach |
| author_sort | Irena Ciećko-Michalska |
| collection | DOAJ |
| description | Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. The influence of small intestine bacterial overgrowth (SIBO) on the induction of minimal hepatic encephalopathy is recently emphasized. The aim of this paper is to present the current views on the pathogenesis of hepatic encephalopathy. |
| format | Article |
| id | doaj-art-0d3ad78c4b964551b229bc12c68a75dc |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0d3ad78c4b964551b229bc12c68a75dc2025-02-03T01:30:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/642108642108Pathogenesis of Hepatic EncephalopathyIrena Ciećko-Michalska0Małgorzata Szczepanek1Agnieszka Słowik2Tomasz Mach3Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Sniadeckich Street 5, 31-531 Krakow, PolandDepartment of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Sniadeckich Street 5, 31-531 Krakow, PolandDepartment of Neurology, Jagiellonian University Medical College, Sniadeckich Street 5, 31-531 Krakow, PolandDepartment of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Sniadeckich Street 5, 31-531 Krakow, PolandHepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. The influence of small intestine bacterial overgrowth (SIBO) on the induction of minimal hepatic encephalopathy is recently emphasized. The aim of this paper is to present the current views on the pathogenesis of hepatic encephalopathy.http://dx.doi.org/10.1155/2012/642108 |
| spellingShingle | Irena Ciećko-Michalska Małgorzata Szczepanek Agnieszka Słowik Tomasz Mach Pathogenesis of Hepatic Encephalopathy Gastroenterology Research and Practice |
| title | Pathogenesis of Hepatic Encephalopathy |
| title_full | Pathogenesis of Hepatic Encephalopathy |
| title_fullStr | Pathogenesis of Hepatic Encephalopathy |
| title_full_unstemmed | Pathogenesis of Hepatic Encephalopathy |
| title_short | Pathogenesis of Hepatic Encephalopathy |
| title_sort | pathogenesis of hepatic encephalopathy |
| url | http://dx.doi.org/10.1155/2012/642108 |
| work_keys_str_mv | AT irenacieckomichalska pathogenesisofhepaticencephalopathy AT małgorzataszczepanek pathogenesisofhepaticencephalopathy AT agnieszkasłowik pathogenesisofhepaticencephalopathy AT tomaszmach pathogenesisofhepaticencephalopathy |