Efficacy and safety of midazolam compared to fentanyl as adjuvants to hyperbaric bupivacaine in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials

Efficacy and safety of midazolam compared to fentanyl as adjuvants to hyperbaric bupivacaine in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials

Abstract Background Various drugs have been used as adjuvants to local anesthetics to prolong analgesia and reduce the dosage and side effects of local anesthetics in regional anesthesia and peripheral nerve blocks. Methods The literature search was conducted using Google Scholar, PubMed, and the Co...

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Main Authors: Molla Amsalu Tadesse, Eniyew Assimie Alemu, Mengesha Dessie Allene, Melkam Mulugeta Abebe, Agmuas Asichale Alimawu, Fetene Seyoum Kebede, Emebet Seyum Wondemu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Anesthesiology
Subjects:
Efficacy
Safety
Spinal anesthesia
Fentanyl
Bupivacaine
Midazolam
Online Access:https://doi.org/10.1186/s12871-025-03261-1
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https://doi.org/10.1186/s12871-025-03261-1

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