Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics

Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics

BackgroundDiabetes mellitus (DM) is a metabolic disease with high morbidity, which significantly affects human life and health expenditures. Previous studies have demonstrated that artemether (ATM) has anti-diabetes and anti-inflammation activities, but its mechanism has not been fully elucidated. T...

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Bibliographic Details
Main Authors: Tao Jiang, Peipei Du, Dongxia Liu, Hetao Chen, Yujin Ma, Bin Hu, Jingna Li, Hongwei Jiang, Xuejiao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
T2DM
network pharmacology
artemether
metabolomics
gut microbiota
AMPK/mTOR pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1520439/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1520439/full

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