In Silico Identification and Characterization of Spiro[1,2,4]triazolo[1,5-<i>c</i>]quinazolines as Diacylglycerol Kinase α Modulators

In Silico Identification and Characterization of Spiro[1,2,4]triazolo[1,5-<i>c</i>]quinazolines as Diacylglycerol Kinase α Modulators

A new class of spiro[1,2,4]triazolo[1,5-<i>c</i>]quinazoline derivatives is presented as promising modulators of diacylglycerol kinase α (DGK-α), a target implicated in cancer, neurological disorders, and immune dysfunction. Through structure-based computational design using the CB-Dock2...

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Bibliographic Details
Main Authors: Lyudmyla Antypenko, Kostiantyn Shabelnyk, Oleksii Antypenko, Mieko Arisawa, Oleksandr Kamyshnyi, Valentyn Oksenych, Serhii Kovalenko
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
diacylglycerol kinase
molecular docking
spirotriazoloquinazolines
structure–activity relationships
computational drug design
Online Access:https://www.mdpi.com/1420-3049/30/11/2324
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