Stearoyl-CoA desaturase 1 deficiency drives saturated lipid accumulation and increases liver and plasma acylcarnitines

Stearoyl-CoA desaturase 1 deficiency drives saturated lipid accumulation and increases liver and plasma acylcarnitines

Stearoyl-CoA desaturase-1 (SCD1) is a critical regulator of lipogenesis that catalyzes the synthesis of MUFAs, mainly oleate (18:1n-9) and palmitoleate (16:1n-7) from saturated fatty acids, stearoyl-CoA (18:0) and palmitoyl-CoA (16:0), respectively. Elevated SCD1 expression and its products are asso...

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Bibliographic Details
Main Authors: Mugagga Kalyesubula, Helaina Von Bank, Jessica W. Davidson, Maggie S. Burhans, Madelaine M. Becker, Ahmed Aljohani, Judith Simcox, James M. Ntambi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Lipid Research
Subjects:
SCD1
SCD5
saturated fatty acid
oleate
acylcarnitines
lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000847
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