Unraveling the significance of cuproptosis in hepatocellular carcinoma heterogeneity and tumor microenvironment through integrated single-cell sequencing and machine learning approaches

Unraveling the significance of cuproptosis in hepatocellular carcinoma heterogeneity and tumor microenvironment through integrated single-cell sequencing and machine learning approaches

Abstract Background Hepatocellular carcinoma (HCC) exhibits pronounced heterogeneity, which significantly limits the effectiveness of precision therapies. A comprehensive understanding of the biological characteristics and molecular mechanisms underlying HCC cell subpopulations is crucial for improv...

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Bibliographic Details
Main Authors: Wang Liu, Liangjing Xia, Yuan peng, Qiang Cao, Ke Xu, Huiyan Luo, Yongjun Peng, Yanping Zhang
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
HCC
Cuproptosis
Single-Cell Sequencing
Machine Learning
Tumor microenvironment
Online Access:https://doi.org/10.1007/s12672-025-02696-9
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https://doi.org/10.1007/s12672-025-02696-9

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