Development and Application of a UPLC–MRM–MS Method for Quantifying Trimethylamine, Trimethylamine-N-Oxide, and Related Metabolites in Individuals with and Without Metabolic Syndrome

Trimethylamine-N-oxide (TMAO) is associated with various chronic diseases. TMAO is a downstream oxidative metabolite of trimethylamine (TMA) that is generated by the gut microbiota from dietary choline, carnitine, and betaine. Current analytical methods predominantly target TMAO only, due to the cha...

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Bibliographic Details
Main Authors: Mohammed E. Hefni, Cornelia M. Witthöft
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Separations
Subjects:
Online Access:https://www.mdpi.com/2297-8739/12/2/53
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