Centella asiatica extract improves senescence-associated metabolic dysfunction by targeting inflammation in adipose tissue and macrophage in obesity-induced insulin resistance mice

Centella asiatica extract improves senescence-associated metabolic dysfunction by targeting inflammation in adipose tissue and macrophage in obesity-induced insulin resistance mice

Insulin Resistance (IR) is a complication that frequently occurs in obesity. The inflammation-mediated senescence in White Adipose Tissue (WAT) is important in obesity-induced IR. Centella asiatica (CA) is a potential medicinal plant with anti-aging and anti-obesity properties. Here, we explored the...

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Bibliographic Details
Main Authors: Agian Jeffilano Barinda, Wawaimuli Arozal, Nounik Cheri Dwita, Muhamad Sadam Safutra, Ippei Shimizu, Yung Ting Hsiao, Normalina Sandora, Rani Wardani Hakim, Nurul Gusti Khatimah, Harri Hardi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
Centella asiatica
inflammation
M1 pro-inflammatory macrophage
senescence
white adipose tissue
obesity
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1589444/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1589444/full

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