Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts.

Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts.

<h4>Background</h4>Mutations in Parkin are the most common cause of autosomal recessive Parkinson disease (PD). The mitochondrially localized E3 ubiquitin-protein ligase Parkin has been reported to be involved in respiratory chain function and mitochondrial dynamics. More recent publicat...

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Main Authors: Anne Grünewald, Lisa Voges, Aleksandar Rakovic, Meike Kasten, Himesha Vandebona, Claudia Hemmelmann, Katja Lohmann, Slobodanka Orolicki, Alfredo Ramirez, Anthony H V Schapira, Peter P Pramstaller, Carolyn M Sue, Christine Klein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012962&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012962&type=printable

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