Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension

Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension

Abstract Background Abnormal glycolytic metabolism plays a significant role in pulmonary vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH), yet the specific mechanisms remain unclear. The primary objective of this study is to investigate the key regulatory mechanisms of glycol...

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Main Authors: Xuan Gao, Youli Fan, Guijia Wang, Jiangjiang Xu, Runwei Deng, Jiangwei Song, Binfeng Sun, Yongbing Wang, Zixuan Wu, Ruyi Jia, Jing Huang, Huiyu He, Lei Gao, Yihao Zhang, Na Sun, Bingxiang Wu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
IPAH
Glycolysis
Single-cell sequencing
Online Access:https://doi.org/10.1186/s12967-025-06373-x
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https://doi.org/10.1186/s12967-025-06373-x

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