Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

BackgroundRadiation therapy, integral to pelvic tumor management, impacts over half of all cancer patients and may lead to anal sphincter dysfunction due to inflammatory responses and chronic fibrotic remodeling in irradiated tissues. To address this, a targeted animal model has been developed to in...

Full description

Saved in:
Bibliographic Details
Main Authors: Dragoș Viorel Scripcariu, Cezar Cătălin Caratașu, Mitică Ciorpac, Teodora Alexa-Stratulat, Andrei Szilagyi, Cristian Răzvan Buga, Bogdan Ionuţ Dobrovăț, Lucian Eva, Andrei Daniel Timofte, Ludmila Lozneanu, Irina-Draga Căruntu, Radu Iliescu, Bogdan Ionel Tamba
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
TGF-β inhibition
radiation induced-anal sphincter dysfunction
antifibrotic therapy
pirfenidone in radiotherapy-induced anal sphincter dysfunction
irradiated anal sphincter remodelling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1441011/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2025.1441011/full

Similar Items