Rapid diagnostic imaging and targeted immunotoxin delivery in aggressive prostate cancer using CEACAM5-specific nanobodies

Rapid diagnostic imaging and targeted immunotoxin delivery in aggressive prostate cancer using CEACAM5-specific nanobodies

Abstract Aggressive variant prostate cancer (AVPC) originates from metastatic prostate cancer (mPCa) following androgen receptor-targeted therapies, leading to diverse pathological subtypes, notably castration-resistant prostate cancer (CRPC). Carcinoembryonic antigen-related cell adhesion molecule...

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Main Authors: Zhaoming Xiao, Jingbo Ma, Jinpeng Cen, Tao Xie, Liuhai Zheng, Guangwei Shi, Zhifen Li, Yang Li, Chengming Qu, Yuanqiao He, Chong Wang, Jun Xiao, Haibo Jiang, Zhijie Li, Jigang Wang, Shan-Chao Zhao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Aggressive variant prostate cancer
Phenotype transformation
CEACAM5
Nanobodies
Rapid imaging
Immunotoxin
Online Access:https://doi.org/10.1186/s12951-025-03600-x
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https://doi.org/10.1186/s12951-025-03600-x

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