A proximity-induced chimera platform for targeted protein arginine methylation

A proximity-induced chimera platform for targeted protein arginine methylation

Arginine methylation is a critical post-translational modification that plays multifaceted biological functions. However, the manipulation of protein arginine methylation largely depends on genetic or pharmaceutic inhibition of the regulatory enzymes, protein arginine methyltransferases (PRMTs), or...

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Bibliographic Details
Main Authors: Yanlin Jian, Tianyang Zhou, Chendong Guo, Yibo Gao, Chen Yao, Zixi Wang, Xuehan Jiang, Ke Wang, Jian Ma, Yang Gao, Yizeng Fan, Jing Liu, Bohan Ma, Lei Li
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Protein arginine methyltransferases
Arginine methylation
Bifunctional molecules
Methylation tagging system
Ternary complex
Androgen receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002175
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