Multiple Enzymes Expressed by the Gut Microbiota Can Transform Typhaneoside and Are Associated with Improving Hyperlipidemia

Multiple Enzymes Expressed by the Gut Microbiota Can Transform Typhaneoside and Are Associated with Improving Hyperlipidemia

Abstract The mechanism of multiple enzymes mediated drug metabolism in gut microbiota is still unclear. This study explores multiple enzyme interaction process of typhactyloside (TYP) with gut microbiota and its lipid‐lowering pharmacological activity. TYP, with bioavailability of only 2.78%, is an...

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Main Authors: Hui Xu, Ru Feng, Meng‐Liang Ye, Jia‐Chun Hu, Jin‐Yue Lu, Jing‐Yue Wang, Heng‐Tong Zuo, Yi Zhao, Jian‐Ye Song, Jian‐Dong Jiang, Yun‐Zhi Zhou, Yan Wang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
α‐rhamnosidase
β‐glucosidase
gut microbiota
hyperlipidemia
short‐chain fatty acid
typhaneoside
Online Access:https://doi.org/10.1002/advs.202411770
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https://doi.org/10.1002/advs.202411770

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