The study of halogen effect on the reactivity of the serine-targeting covalent warheads

The study of halogen effect on the reactivity of the serine-targeting covalent warheads

Halogens favorably contributes to the drug potency and metabolic stability via electrostatic interactions. Herein, the halogen effects on the reactivity of the halogenated 2,2,2-trifluoroacetophenones as serine-targeting covalent warheads were investigated. Our results showed that introducing haloge...

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Bibliographic Details
Main Authors: Conghao Gai, Ya Zhang, Shihao Zhang, Xueyan Hu, Yun-Qing Song, Xiaoyu Zhuang, Xiaoyun Chai, Yan Zou, Guang-Bo Ge, Qingjie Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Chemistry
Subjects:
hCES1A
covalent warheads
2,2,2-trifluoroacetophenones
serine-targeted reactivity
halogen effect
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1504453/full
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https://www.frontiersin.org/articles/10.3389/fchem.2024.1504453/full

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