Colorectal Perforation in Patients with Connective Tissue Disease
Purpose. The goal of this retrospective study was to identify prognostic factors associated with mortality after surgery for colorectal perforation among patients with connective tissue disease (CTD) and to review postoperative outcomes based on these prognostic factors. Methods. The subjects were 1...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2019/5852438 |
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| author | Kiichi Sugimoto Kazuhiro Sakamoto Yu Okazawa Rina Takahashi Kosuke Mizukoshi Hisashi Ro Masaya Kawai Shingo Kawano Shinya Munakata Shun Ishiyama Hirohiko Kamiyama Makoto Takahashi Yutaka Kojima Yuichi Tomiki Naoto Tamura |
| author_facet | Kiichi Sugimoto Kazuhiro Sakamoto Yu Okazawa Rina Takahashi Kosuke Mizukoshi Hisashi Ro Masaya Kawai Shingo Kawano Shinya Munakata Shun Ishiyama Hirohiko Kamiyama Makoto Takahashi Yutaka Kojima Yuichi Tomiki Naoto Tamura |
| author_sort | Kiichi Sugimoto |
| collection | DOAJ |
| description | Purpose. The goal of this retrospective study was to identify prognostic factors associated with mortality after surgery for colorectal perforation among patients with connective tissue disease (CTD) and to review postoperative outcomes based on these prognostic factors. Methods. The subjects were 105 patients (CTD group: n=26, 24.8%; non-CTD group: n=79, 75.2%) who underwent surgery for colorectal perforation at our department. Cases with iatrogenic perforation due to colonoscopic examination were excluded from the study. We retrospectively investigated perioperative clinicopathological factors in patients undergoing surgery for colorectal perforation. Results. There were 7 patients (6.7%) who died within 28 days after surgery in all patients. In multivariate analysis, CTD and fecal peritonitis emerged as significant independent prognostic factors (p=0.005, odds ratio=12.39; p=0.04, odds ratio=7.10, respectively). There were 5 patients (19.2%) who died within 28 days after surgery in the CTD group. In multivariate analysis, fecal peritonitis emerged as a significant independent prognostic factor in the CTD group (p=0.03, odds ratio=31.96). The cumulative survival curve in the CTD group was significantly worse than that in the non-CTD group (p=0.006). An analysis based on the presence of fecal peritonitis indicated no significant difference in cumulative survival curves for patients without fecal peritonitis in the CTD and non-CTD groups (p=0.55) but a significant difference in these curves for patients with fecal peritonitis in the two groups (p<0.0001). Conclusions. This study demonstrated that cumulative survival in patients with CTD is significantly worse than that in patients without CTD after surgery for colorectal perforation. |
| format | Article |
| id | doaj-art-0c8ad9ff368e4b508dbf08fa61d4047b |
| institution | Kabale University |
| issn | 2090-2840 2090-2859 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-0c8ad9ff368e4b508dbf08fa61d4047b2025-02-03T01:32:51ZengWileyEmergency Medicine International2090-28402090-28592019-01-01201910.1155/2019/58524385852438Colorectal Perforation in Patients with Connective Tissue DiseaseKiichi Sugimoto0Kazuhiro Sakamoto1Yu Okazawa2Rina Takahashi3Kosuke Mizukoshi4Hisashi Ro5Masaya Kawai6Shingo Kawano7Shinya Munakata8Shun Ishiyama9Hirohiko Kamiyama10Makoto Takahashi11Yutaka Kojima12Yuichi Tomiki13Naoto Tamura14Department of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Coloproctological Surgery, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanDepartment of Rheumatology, Juntendo University, Faculty of Medicine, Tokyo 113-8421, JapanPurpose. The goal of this retrospective study was to identify prognostic factors associated with mortality after surgery for colorectal perforation among patients with connective tissue disease (CTD) and to review postoperative outcomes based on these prognostic factors. Methods. The subjects were 105 patients (CTD group: n=26, 24.8%; non-CTD group: n=79, 75.2%) who underwent surgery for colorectal perforation at our department. Cases with iatrogenic perforation due to colonoscopic examination were excluded from the study. We retrospectively investigated perioperative clinicopathological factors in patients undergoing surgery for colorectal perforation. Results. There were 7 patients (6.7%) who died within 28 days after surgery in all patients. In multivariate analysis, CTD and fecal peritonitis emerged as significant independent prognostic factors (p=0.005, odds ratio=12.39; p=0.04, odds ratio=7.10, respectively). There were 5 patients (19.2%) who died within 28 days after surgery in the CTD group. In multivariate analysis, fecal peritonitis emerged as a significant independent prognostic factor in the CTD group (p=0.03, odds ratio=31.96). The cumulative survival curve in the CTD group was significantly worse than that in the non-CTD group (p=0.006). An analysis based on the presence of fecal peritonitis indicated no significant difference in cumulative survival curves for patients without fecal peritonitis in the CTD and non-CTD groups (p=0.55) but a significant difference in these curves for patients with fecal peritonitis in the two groups (p<0.0001). Conclusions. This study demonstrated that cumulative survival in patients with CTD is significantly worse than that in patients without CTD after surgery for colorectal perforation.http://dx.doi.org/10.1155/2019/5852438 |
| spellingShingle | Kiichi Sugimoto Kazuhiro Sakamoto Yu Okazawa Rina Takahashi Kosuke Mizukoshi Hisashi Ro Masaya Kawai Shingo Kawano Shinya Munakata Shun Ishiyama Hirohiko Kamiyama Makoto Takahashi Yutaka Kojima Yuichi Tomiki Naoto Tamura Colorectal Perforation in Patients with Connective Tissue Disease Emergency Medicine International |
| title | Colorectal Perforation in Patients with Connective Tissue Disease |
| title_full | Colorectal Perforation in Patients with Connective Tissue Disease |
| title_fullStr | Colorectal Perforation in Patients with Connective Tissue Disease |
| title_full_unstemmed | Colorectal Perforation in Patients with Connective Tissue Disease |
| title_short | Colorectal Perforation in Patients with Connective Tissue Disease |
| title_sort | colorectal perforation in patients with connective tissue disease |
| url | http://dx.doi.org/10.1155/2019/5852438 |
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