CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma

CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma

Abstract Esophageal squamous cell carcinoma (ESCC) is associated with a highly immunosuppressive tumor microenvironment (TME), driven in part by cancer-associated fibroblasts (CAFs) that promote immune evasion through the secretion of CXCL12. CXCL12 interacts with the CXCR4 receptor on immune cells,...

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Main Authors: Shuyao Zhang, Hong Jiang, Chengkuan Zhao, Yanli Lei, Shaojie Liu, Chengcheng Xu, Xiaoshan Chen, Danling Zheng, Xiaolong Wu, Xinyue Lin, Wang Chen, Yun Chen, Jianxiang Huang, XiaoLong Wei, Yihui Huang, Chaoxian Lin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Esophageal squamous cell carcinoma
Tumor microenvironment
Cancer-associated fibroblasts
CXCL12
SiRNA nanoparticles
Online Access:https://doi.org/10.1186/s12951-025-03476-x
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https://doi.org/10.1186/s12951-025-03476-x

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