Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia
Purpose. The aim of this study is to determine the incidence and the predictors of ocular candidiasis among patient with Candida fungemia. Methods. We retrospectively reviewed the charts of all patients diagnosed with candidemia at the University of Kansas Medical Center during February 2000–March 2...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/650235 |
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| author | Ayesha Khalid Lisa A. Clough R. C. Andrew Symons Jonathan D. Mahnken Lei Dong Albert J. Eid |
| author_facet | Ayesha Khalid Lisa A. Clough R. C. Andrew Symons Jonathan D. Mahnken Lei Dong Albert J. Eid |
| author_sort | Ayesha Khalid |
| collection | DOAJ |
| description | Purpose. The aim of this study is to determine the incidence and the predictors of ocular candidiasis among patient with Candida fungemia. Methods. We retrospectively reviewed the charts of all patients diagnosed with candidemia at the University of Kansas Medical Center during February 2000–March 2010. Data regarding patients’ demographics, clinical characteristics, laboratory results, and ophthalmology examination findings were collected. Results. A total of 283 patients with candidemia were enrolled. The mean age (± standard deviation) was 55 ± 18 years; 66% were male. The most commonly isolated Candida species were C. albicans (54%), C. parapsilosis (20%), C. glabrata (13%), and C. tropicalis (8%). Only 144 (51%) patients were evaluated by ophthalmology; however, the proportion of patients who were formally evaluated by an ophthalmologist increased during the study period (9%in 2000 up to 73%in 2010; P<0.0001). Evidence of ocular candidiasis was present in 18 (12.5%) patients. Visual symptoms were reported by 5 of 18 (28%) patients. In multivariable analysis, no predictors of ocular candidiasis were identified. Conclusions. The incidence of ocular candidiasis among patients with fungemia remains elevated. Most patients are asymptomatic and therefore all patients with candidemia should undergo fundoscopic examination to rule out ocular involvement. |
| format | Article |
| id | doaj-art-0c6c9cbfab8640b1910c0debbe1577e9 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-0c6c9cbfab8640b1910c0debbe1577e92025-02-03T01:03:45ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982014-01-01201410.1155/2014/650235650235Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida FungemiaAyesha Khalid0Lisa A. Clough1R. C. Andrew Symons2Jonathan D. Mahnken3Lei Dong4Albert J. Eid5Division of Infectious Diseases, University of Kansas Medical Center, 2067 Delp, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADivision of Infectious Diseases, University of Kansas Medical Center, 2067 Delp, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADepartment of Ophthalmology, Royal Melbourne Hospital, Parkville, VIC 3050, AustraliaDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS 66160, USADivision of Infectious Diseases, University of Kansas Medical Center, 2067 Delp, 3901 Rainbow Boulevard, Kansas City, KS 66160, USAPurpose. The aim of this study is to determine the incidence and the predictors of ocular candidiasis among patient with Candida fungemia. Methods. We retrospectively reviewed the charts of all patients diagnosed with candidemia at the University of Kansas Medical Center during February 2000–March 2010. Data regarding patients’ demographics, clinical characteristics, laboratory results, and ophthalmology examination findings were collected. Results. A total of 283 patients with candidemia were enrolled. The mean age (± standard deviation) was 55 ± 18 years; 66% were male. The most commonly isolated Candida species were C. albicans (54%), C. parapsilosis (20%), C. glabrata (13%), and C. tropicalis (8%). Only 144 (51%) patients were evaluated by ophthalmology; however, the proportion of patients who were formally evaluated by an ophthalmologist increased during the study period (9%in 2000 up to 73%in 2010; P<0.0001). Evidence of ocular candidiasis was present in 18 (12.5%) patients. Visual symptoms were reported by 5 of 18 (28%) patients. In multivariable analysis, no predictors of ocular candidiasis were identified. Conclusions. The incidence of ocular candidiasis among patients with fungemia remains elevated. Most patients are asymptomatic and therefore all patients with candidemia should undergo fundoscopic examination to rule out ocular involvement.http://dx.doi.org/10.1155/2014/650235 |
| spellingShingle | Ayesha Khalid Lisa A. Clough R. C. Andrew Symons Jonathan D. Mahnken Lei Dong Albert J. Eid Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia Interdisciplinary Perspectives on Infectious Diseases |
| title | Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia |
| title_full | Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia |
| title_fullStr | Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia |
| title_full_unstemmed | Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia |
| title_short | Incidence and Clinical Predictors of Ocular Candidiasis in Patients with Candida Fungemia |
| title_sort | incidence and clinical predictors of ocular candidiasis in patients with candida fungemia |
| url | http://dx.doi.org/10.1155/2014/650235 |
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