VEGF blockade enhances the antitumor effect of BRAFV600E inhibition

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition

Abstract The development of resistance remains a major obstacle to long‐term disease control in cancer patients treated with targeted therapies. In BRAF‐mutant mouse models, we demonstrate that although targeted inhibition of either BRAF or VEGF initially suppresses the growth of BRAF‐mutant tumors,...

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Main Authors: Valentina Comunanza, Davide Corà, Francesca Orso, Francesca Maria Consonni, Emanuele Middonti, Federica Di Nicolantonio, Anton Buzdin, Antonio Sica, Enzo Medico, Dario Sangiolo, Daniela Taverna, Federico Bussolino
Format: Article
Language:English
Published: Springer Nature 2016-12-01
Series:EMBO Molecular Medicine
Subjects:
angiogenesis
drug resistance
extracellular matrix
myeloid infiltration
vascular normalization
Online Access:https://doi.org/10.15252/emmm.201505774
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https://doi.org/10.15252/emmm.201505774

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