A novel photocleavable amino-modified graphene for covalent purification of N-glycans from hepatocellular carcinoma patients’ serum for potential biomarkers discovery

A novel photocleavable amino-modified graphene for covalent purification of N-glycans from hepatocellular carcinoma patients’ serum for potential biomarkers discovery

Abstract Glycosylation alterations have emerged as significant indicators in the landscape of cancer diagnosis, with aberrant N-glycans standing out as potential biomarkers. The existing methods for purifying N-glycans mainly rely on their hydrophilicity, affinity, and size. These methods exhibit re...

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Bibliographic Details
Main Authors: Xuyuan Chao, Shengjie Yang, Baoying Zhang, Xin Zang, Jingyi Zhang, Xizi Liu, Lu Chen, Lu Qi, Xiaofeng Xue, Han Hu, Xinghe Wang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer Nanotechnology
Subjects:
Photocleavable amino graphene
N-Glycans
Human serum
Hepatocellular carcinoma
Cancer biomarker
MALDI-TOF/TOF MS
Online Access:https://doi.org/10.1186/s12645-024-00304-z
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https://doi.org/10.1186/s12645-024-00304-z

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