Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in nasopharyngeal carcinoma

Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in nasopharyngeal carcinoma

Abstract Aberrant vascular systems are significant indicators of cancer and play pivotal roles in tumor immunomodulation. However, the role of PD-L1 expressed on vascular endothelial cells (VECs) in the tumor immune microenvironment of nasopharyngeal carcinoma (NPC), as well as its correlation with...

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Main Authors: Yan Wang, Yuanyuan Chen, Yuanyuan Liu, Jingjing Zhao, Gongming Wang, Hao Chen, Yan Tang, Dijun Ouyang, Songzuo Xie, Jinqi You, Xinyi Yang, Minxing Li, Jianchuan Xia, Tong Xiang, Desheng Weng
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07444-z
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https://doi.org/10.1038/s41419-025-07444-z

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