Computational models reveal a passive mechanism for cell migration in the crypt.

Cell migration in the intestinal crypt is essential for the regular renewal of the epithelium, and the continued upward movement of cells is a key characteristic of healthy crypt dynamics. However, the driving force behind this migration is unknown. Possibilities include mitotic pressure, active mov...

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Bibliographic Details
Main Authors: Sara-Jane Dunn, Inke S Näthke, James M Osborne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0080516
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