Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation

Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation

Abstract Local haemodynamics control arterial homeostasis and dysfunction by generating wall shear stress (WSS) which regulates endothelial cell (EC) physiology. Here we use a zebrafish model to identify genes that regulate EC proliferation in response to flow. Suppression of blood flow in zebrafish...

Full description

Saved in:
Bibliographic Details
Main Authors: George Bowley, Sophie Irving, Imo Hoefer, Robert Wilkinson, Gerard Pasterkamp, Hazem M. S. Darwish, Stephen White, Sheila E. Francis, Tim Chico, Emily Noel, Jovana Serbanovic-Canic, Paul C. Evans
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Endothelial cells
Shear stress
WNK1
Proliferation
Online Access:https://doi.org/10.1038/s41598-024-77370-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-024-77370-1

Similar Items