Ethyl acetate extract of Ruta graveolens: a specific and potent inhibitor against the drug-resistant EGFR_T790M mutant in NSCLC

Ethyl acetate extract of Ruta graveolens: a specific and potent inhibitor against the drug-resistant EGFR_T790M mutant in NSCLC

Lung cancer, the second leading cause of cancer mortality, requires the development of novel therapeutic strategies due to emerging drug resistance and toxicity. With this objective, the present work explored the therapeutic potential of R. graveolens leaf extracts against EGFR_T790M-mediated drug r...

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Main Authors: Vikas Kumar, Leena Chauhan, Deepa Singh, Akash Kumar, Rajkumar Kulandaisamy, Tushar Kushwaha, Kamal Baswal, Rajan Singh, Saroj Kumar, Shivajirao L. Gholap, P. Hariprasad, S. Babu Dadinaboyina, Jagadeshwar R. Thota, Deepak Sehgal, Mohan B. Appaiahgari, Krishna K. Inampudi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
Lung cancer
NSCLC
EGFR_T790M mutation
Ruta graveolens
ethyl acetate extract
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1570108/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1570108/full

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