Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival

Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival

IntroductionAdvanced thyroid cancer, including papillary (PTC) and anaplastic thyroid cancer (ATC), are the leading causes of endocrine cancer deaths. Thus, there is a critical need to identify novel therapeutic targets to improve standard of care. Focal Adhesion Kinase (FAK) is overexpressed and ph...

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Bibliographic Details
Main Authors: Meghan D. Kellett, Vibha Sharma, Madeline E. Sherlock, Umarani Pugazhenthi, Madison M. Rose, Molishree U. Joshi, Monika Dzieciatkowska, Vu Nguyen, Philip Reigan, Kirk C. Hansen, Jeffrey S. Kieft, Rebecca E. Schweppe
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
thyroid cancer
focal adhesion kinase
nucleolus
ribosomal biogenesis
NOP56
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1252544/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1252544/full

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