The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior

The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior

Abstract Background Recent research from our group has shown that the overexpression of the wild-type RAS-family GTPase RRAS2 drives the onset of triple-negative breast cancer (TNBC) in mice following one or more pregnancies. This phenomenon mirrors human TNBC, where RRAS2 is overexpressed in approx...

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Main Authors: Claudia Cifuentes, Lydia Horndler, Pilar Grosso, Clara L Oeste, Alejandro M. Hortal, Jennifer Castillo, Isabel Fernández-Pisonero, Alberto Paradela, Xosé Bustelo, Balbino Alarcón
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Hematology & Oncology
Subjects:
Triple negative breast cancer
Postpartum-associated breast cancer
CD44
Interaction with the extracellular matrix
Cell migration and invasion
Metastasis
Online Access:https://doi.org/10.1186/s13045-025-01693-3
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https://doi.org/10.1186/s13045-025-01693-3

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