The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial
Abnormal synaptic maturation and connectivity are possible etiologies of autism. Previous studies showed significantly less alpha activity in autism than normal children. Therefore, we studied the effects of anodal tDCS on peak alpha frequency (PAF) related to autism treatment evaluation checklist (...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/928631 |
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| author | Anuwat Amatachaya Mark P. Jensen Niramol Patjanasoontorn Narong Auvichayapat Chanyut Suphakunpinyo Suparerk Janjarasjitt Niran Ngernyam Benchaporn Aree-uea Paradee Auvichayapat |
| author_facet | Anuwat Amatachaya Mark P. Jensen Niramol Patjanasoontorn Narong Auvichayapat Chanyut Suphakunpinyo Suparerk Janjarasjitt Niran Ngernyam Benchaporn Aree-uea Paradee Auvichayapat |
| author_sort | Anuwat Amatachaya |
| collection | DOAJ |
| description | Abnormal synaptic maturation and connectivity are possible etiologies of autism. Previous studies showed significantly less alpha activity in autism than normal children. Therefore, we studied the effects of anodal tDCS on peak alpha frequency (PAF) related to autism treatment evaluation checklist (ATEC). Twenty male children with autism were randomly assigned in a crossover design to receive a single session of both active and sham tDCS stimulation (11 mA) over F3 (left dorsolateral prefrontal cortex). Pre- to postsession changes in a measure of cortical activity impacted by tDCS (PAF) and ATEC were compared between groups. We also examined the associations between pre- and postsession changes in the PAF and ATEC. The results show significant pre- to postsession improvements in two domains of ATEC (social and health/behavior domains) following active tDCS, relative to sham treatment. PAF also significantly increased at the stimulation site, and an increase in PAF was significantly associated with improvements in the two domains of ATEC impacted by tDCS. The findings suggest that a single session of anodal tDCS over the F3 may have clinical benefits in children with autism and that those benefits may be related to an increase in PAF. |
| format | Article |
| id | doaj-art-0c04ddaf2673494b9a2c8f88ed657b74 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-0c04ddaf2673494b9a2c8f88ed657b742025-02-03T01:06:20ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/928631928631The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled TrialAnuwat Amatachaya0Mark P. Jensen1Niramol Patjanasoontorn2Narong Auvichayapat3Chanyut Suphakunpinyo4Suparerk Janjarasjitt5Niran Ngernyam6Benchaporn Aree-uea7Paradee Auvichayapat8Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Rehabilitation Medicine, University of Washington, 1959 NE Pacific Street, P.O. Box 356490, Seattle, WA 98195-6490, USADepartment of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Electrical and Electronic Engineering, Faculty of Engineering, Ubon Ratchathani University, Ubon Ratchathani 34190, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandAbnormal synaptic maturation and connectivity are possible etiologies of autism. Previous studies showed significantly less alpha activity in autism than normal children. Therefore, we studied the effects of anodal tDCS on peak alpha frequency (PAF) related to autism treatment evaluation checklist (ATEC). Twenty male children with autism were randomly assigned in a crossover design to receive a single session of both active and sham tDCS stimulation (11 mA) over F3 (left dorsolateral prefrontal cortex). Pre- to postsession changes in a measure of cortical activity impacted by tDCS (PAF) and ATEC were compared between groups. We also examined the associations between pre- and postsession changes in the PAF and ATEC. The results show significant pre- to postsession improvements in two domains of ATEC (social and health/behavior domains) following active tDCS, relative to sham treatment. PAF also significantly increased at the stimulation site, and an increase in PAF was significantly associated with improvements in the two domains of ATEC impacted by tDCS. The findings suggest that a single session of anodal tDCS over the F3 may have clinical benefits in children with autism and that those benefits may be related to an increase in PAF.http://dx.doi.org/10.1155/2015/928631 |
| spellingShingle | Anuwat Amatachaya Mark P. Jensen Niramol Patjanasoontorn Narong Auvichayapat Chanyut Suphakunpinyo Suparerk Janjarasjitt Niran Ngernyam Benchaporn Aree-uea Paradee Auvichayapat The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial Behavioural Neurology |
| title | The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial |
| title_full | The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial |
| title_fullStr | The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial |
| title_full_unstemmed | The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial |
| title_short | The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial |
| title_sort | short term effects of transcranial direct current stimulation on electroencephalography in children with autism a randomized crossover controlled trial |
| url | http://dx.doi.org/10.1155/2015/928631 |
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