Depletion of γ-glutamyl cyclotransferase suppresses the proliferation, migration and invasion of breast cancer cells accompanied by the activation of PI3K/AKT/mTOR pathway

Depletion of γ-glutamyl cyclotransferase suppresses the proliferation, migration and invasion of breast cancer cells accompanied by the activation of PI3K/AKT/mTOR pathway

Abstract Breast cancer is a prevalent and deadly disease affecting women worldwide. Recent studies have shown that γ-glutamyl cyclotransferase (GGCT), an enzyme involved in glutathione metabolism, is consistently upregulated in various cancers. However, its specific role in breast cancer remains poo...

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Bibliographic Details
Main Authors: De He, Weiheng Cui, Xijiao Pang, Jiale Dong, Quanwei Qiu, Hongmei Dong, Ruijun Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Breast cancer
γ-Glutamyl cyclotransferase
Proliferation
Migration
Invasion
Prognosis
Online Access:https://doi.org/10.1038/s41598-025-04500-8
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https://doi.org/10.1038/s41598-025-04500-8

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