BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovarian cancer

BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovarian cancer

Abstract Background In high-grade ovarian cancer (HGOC), determination of homologous recombination deficiency (HRD) status is commonly used in routine practice to predict response to platinum-based therapy or poly (ADP-ribose) polymerase inhibitors (PARPi). Here we tested the hypothesis that BRCA lo...

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Bibliographic Details
Main Authors: Heidelinde Fiegl, Simon Schnaiter, Daniel U. Reimer, Katharina Leitner, Petra Nardelli, Irina Tsibulak, Verena Wieser, Katharina Wimmer, Esther Schamschula, Christian Marth, Alain G. Zeimet
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Clinical Epigenetics
Subjects:
Ovarian cancer
BRCA1
BRCA2
DNA-methylation
Homologous recombination deficiency (HRD)
Platinum sensitivity
Online Access:https://doi.org/10.1186/s13148-024-01781-0
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https://doi.org/10.1186/s13148-024-01781-0

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