Fungal Δ9-fatty acid desaturase: a unique enzyme at the core of lipid metabolism in Aspergillus fumigatus and a promising target for the search for antifungal strategies

Fungal Δ9-fatty acid desaturase: a unique enzyme at the core of lipid metabolism in Aspergillus fumigatus and a promising target for the search for antifungal strategies

ABSTRACT Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans are the leading fungal pathogens that cause life-threatening deep mycosis, posing significant challenges to immunocompromised patients and increasing healthcare costs worldwide. Lipid metabolism is crucial for the growth a...

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Bibliographic Details
Main Authors: Jonatas Erick Maimoni Campanella, Leonardo Talachia Rosa, Iran Malavazi
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
sdeA
Δ9-fatty acid desaturase
OLE1
unsaturated fatty acid
Aspergillus fumigatus
antifungals
Online Access:https://journals.asm.org/doi/10.1128/mbio.00803-24
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https://journals.asm.org/doi/10.1128/mbio.00803-24

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