Construction of an EGFP-embedded porcine reproductive and respiratory syndrome virus infectious clone and antiviral drug screening

Construction of an EGFP-embedded porcine reproductive and respiratory syndrome virus infectious clone and antiviral drug screening

Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant pathogen posed a serious threat to the global swine industry. In this study, a BAC-based reverse genetics platform was established using a highly pathogenic PRRSV (HP-PRRSV) strain. Three recombinant reporter viruses were c...

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Bibliographic Details
Main Authors: Rongxiao Liu, Shi Fu, Yukun Chai, Nian Liu, Benjin Liu, Lingzhi Luo, Wei Yang, Xiumei Dong, Jin Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
PRRSV
BAC
EGFP
antiviral drug screening
reverse genetics system
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1653170/full
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