Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile
This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical me...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/217039 |
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| author | Konstantin V. Kudryavtsev Anna O. Markevich Oleksandr V. Virchenko Tetyana M. Falalyeyeva Tetyana V. Beregova Lyudmyla I. Ostapchenko Dmitry V. Zabolotnev Nikolay S. Zefirov |
| author_facet | Konstantin V. Kudryavtsev Anna O. Markevich Oleksandr V. Virchenko Tetyana M. Falalyeyeva Tetyana V. Beregova Lyudmyla I. Ostapchenko Dmitry V. Zabolotnev Nikolay S. Zefirov |
| author_sort | Konstantin V. Kudryavtsev |
| collection | DOAJ |
| description | This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluated in vivo at water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. Prophylactic single-dose 1 mg/kg treatment with (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline efficiently decreases up to 86% stress-induced stomach ulceration in rats. Discovered small-molecule antiulcer agents modulate activities of gastric mucosa tissue superoxide dismutase, catalase, and xanthine oxidase in concerted directions. Gastroprotective effect of (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline at least partially depends on the correction of gastric mucosa oxidative balance. |
| format | Article |
| id | doaj-art-0bb4fccfb4aa4a6f94849aeb97b1dfae |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0bb4fccfb4aa4a6f94849aeb97b1dfae2025-02-03T07:23:55ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/217039217039Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant ProfileKonstantin V. Kudryavtsev0Anna O. Markevich1Oleksandr V. Virchenko2Tetyana M. Falalyeyeva3Tetyana V. Beregova4Lyudmyla I. Ostapchenko5Dmitry V. Zabolotnev6Nikolay S. Zefirov7Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, RussiaInstitute of Biology, Taras Shevchenko National University of Kyiv, Kyiv 03022, UkraineInstitute of Biology, Taras Shevchenko National University of Kyiv, Kyiv 03022, UkraineInstitute of Biology, Taras Shevchenko National University of Kyiv, Kyiv 03022, UkraineInstitute of Biology, Taras Shevchenko National University of Kyiv, Kyiv 03022, UkraineInstitute of Biology, Taras Shevchenko National University of Kyiv, Kyiv 03022, UkraineDepartment of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, RussiaDepartment of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, RussiaThis study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluated in vivo at water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. Prophylactic single-dose 1 mg/kg treatment with (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline efficiently decreases up to 86% stress-induced stomach ulceration in rats. Discovered small-molecule antiulcer agents modulate activities of gastric mucosa tissue superoxide dismutase, catalase, and xanthine oxidase in concerted directions. Gastroprotective effect of (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline at least partially depends on the correction of gastric mucosa oxidative balance.http://dx.doi.org/10.1155/2014/217039 |
| spellingShingle | Konstantin V. Kudryavtsev Anna O. Markevich Oleksandr V. Virchenko Tetyana M. Falalyeyeva Tetyana V. Beregova Lyudmyla I. Ostapchenko Dmitry V. Zabolotnev Nikolay S. Zefirov Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile The Scientific World Journal |
| title | Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile |
| title_full | Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile |
| title_fullStr | Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile |
| title_full_unstemmed | Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile |
| title_short | Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile |
| title_sort | pharmacological correction of stress induced gastric ulceration by novel small molecule agents with antioxidant profile |
| url | http://dx.doi.org/10.1155/2014/217039 |
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