Synthesis and Biological Evaluation of <i>β</i>-Phenylalanine Derivatives Containing Sulphonamide and Azole Moieties as Antiproliferative Candidates in Lung Cancer Models

Synthesis and Biological Evaluation of <i>β</i>-Phenylalanine Derivatives Containing Sulphonamide and Azole Moieties as Antiproliferative Candidates in Lung Cancer Models

In this study, a series of novel <i>β</i>-phenylalanine derivatives were synthesised and evaluated for their anticancer activity. The 3-(4-methylbenzene-1-sulfonamido)-3-phenylpropanoic acid (<b>2</b>) was prepared using <i>β</i>-phenylalanine as a core scaffold....

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Main Authors: Vytautas Mickevičius, Kazimieras Anusevičius, Birutė Sapijanskaitė-Banevič, Ilona Jonuškienė, Linas Kapočius, Birutė Grybaitė, Ramunė Grigalevičiūtė, Povilas Kavaliauskas
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Molecules
Subjects:
oxadiazole
triazole
1,2,4-triazolo [3,4-<i>b</i>][1,3,4]thiadiazine
sulphanilamide
β-phenylalanine
azole
Online Access:https://www.mdpi.com/1420-3049/30/15/3303
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