Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes

Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes

Summary: In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca2+-binding/trafficking protein, Cab45G, serves as a non-essential chaperone for insulin granule bioge...

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Main Authors: Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Biological sciences
Cell biology
Organizational aspects of cell biology
Specialized functions of cells
Functional aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224029468
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