YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis

YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis

Abstract Background As a member of the family of the YTH domain and a an m6A reader, YTHDF3 is implicated in cancer and inflammatory diseases. However, its function in ankylosing spondylitis (AS)—a chronic inflammatory disease marked by aberrant bone formation—is still mysterious. The research set o...

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Bibliographic Details
Main Authors: Bole Zhou, Xinzhe Feng, Changhao Han, Yang Wu, Junjie Qiao, Wenwen Tong, Weidong Xu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Ankylosing spondylitis
Mesenchymal stem cell
YTHDF3
Osteogenic differentiation
Online Access:https://doi.org/10.1186/s12967-025-06607-y
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https://doi.org/10.1186/s12967-025-06607-y

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