Retroelement co-option disrupts the cancer transcriptional programme

Retroelement co-option disrupts the cancer transcriptional programme

Abstract Background Transcriptional activation of otherwise repressed retrotransposable elements (RTEs) is a hallmark of cancer, shaping tumour progression and immunogenicity by multifaceted, yet incompletely understood, mechanisms. Methods We used an extended pan-cancer transcriptome assembly to id...

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Bibliographic Details
Main Authors: Jane Loong, Rachael Thompson, Callum Hall, Laura Doglio, Judith Pape, Tobias Plowman, George Kassiotis
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Medicine
Subjects:
Cancer
Retrotransposable elements
Isoform switching
Transcriptional disruption
Online Access:https://doi.org/10.1186/s13073-025-01479-9
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https://doi.org/10.1186/s13073-025-01479-9

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