Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study
Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints. The inflammation of the synovium can be observed in both of the two diseases. Synovial fibroblasts (SFs) play an important role in the inflammatory process of the synovium. The functional...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4080735 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551371014930432 |
|---|---|
| author | Shaozhe Cai Bingxia Ming Cong Ye Shengyan Lin Peng Hu Jungen Tang Fang Zheng Lingli Dong |
| author_facet | Shaozhe Cai Bingxia Ming Cong Ye Shengyan Lin Peng Hu Jungen Tang Fang Zheng Lingli Dong |
| author_sort | Shaozhe Cai |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints. The inflammation of the synovium can be observed in both of the two diseases. Synovial fibroblasts (SFs) play an important role in the inflammatory process of the synovium. The functional states of synovial fibroblasts are heterogeneous, and the detailed transition process of their functional states is still unclear. By using transcriptomic data of SFs at a single-cell level, we found a similar transition process for SFs in RA and OA. We also identified the potential regulatory effects of the WNT signaling pathway, the TGF-β signaling pathway, the FcεRI signaling pathway, and the ERBB signaling pathway on modifying the SFs’ functional state. These findings indicate potentially overlapped pathogenic mechanisms in these two diseases, which may help uncover new therapeutic targets to ameliorate disease progression. |
| format | Article |
| id | doaj-art-0b5da64bfe6b4834b5931dde30e91d41 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0b5da64bfe6b4834b5931dde30e91d412025-02-03T06:01:36ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/40807354080735Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell StudyShaozhe Cai0Bingxia Ming1Cong Ye2Shengyan Lin3Peng Hu4Jungen Tang5Fang Zheng6Lingli Dong7Department of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, ChinaRheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints. The inflammation of the synovium can be observed in both of the two diseases. Synovial fibroblasts (SFs) play an important role in the inflammatory process of the synovium. The functional states of synovial fibroblasts are heterogeneous, and the detailed transition process of their functional states is still unclear. By using transcriptomic data of SFs at a single-cell level, we found a similar transition process for SFs in RA and OA. We also identified the potential regulatory effects of the WNT signaling pathway, the TGF-β signaling pathway, the FcεRI signaling pathway, and the ERBB signaling pathway on modifying the SFs’ functional state. These findings indicate potentially overlapped pathogenic mechanisms in these two diseases, which may help uncover new therapeutic targets to ameliorate disease progression.http://dx.doi.org/10.1155/2019/4080735 |
| spellingShingle | Shaozhe Cai Bingxia Ming Cong Ye Shengyan Lin Peng Hu Jungen Tang Fang Zheng Lingli Dong Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study Journal of Immunology Research |
| title | Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study |
| title_full | Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study |
| title_fullStr | Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study |
| title_full_unstemmed | Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study |
| title_short | Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study |
| title_sort | similar transition processes in synovial fibroblasts from rheumatoid arthritis and osteoarthritis a single cell study |
| url | http://dx.doi.org/10.1155/2019/4080735 |
| work_keys_str_mv | AT shaozhecai similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy AT bingxiaming similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy AT congye similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy AT shengyanlin similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy AT penghu similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy AT jungentang similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy AT fangzheng similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy AT linglidong similartransitionprocessesinsynovialfibroblastsfromrheumatoidarthritisandosteoarthritisasinglecellstudy |